|SREL Reprint #1933|
THE ASSOCIATION OF DNA DAMAGE TO
CONCENTRATIONS OF MERCURY AND
RADIOCESIUM IN LARGEMOUTH BASS
Abstract - Largemouth bass from five lakes were examined to determine levels
of contamination by mercury and radiocesium and amounts of DNA damage.
Concentrations of these toxicants and an index of body condition were regressed
against overall DNA damage and DNA damage in individual tissues (liver, gills,
and red blood cells) as indicated by the alkaline unwinding method. Sample sites
showed considerable heterogeneity in concentrations of mercury and
radiocesium, as well as numbers of DNA strand breaks. Generally, increased
concentrations of toxicants were related to increased DNA damage. Tissues may
have responded to contaminants in different manners; red blood cells generally
showed the greatest DNA damage while liver tissue showed the least. Although
body condition was related to DNA damage, it is unclear whether it has a direct
effect or whether it is a correlated response to contamination by mercury and
radiocesium. The potential for repair of DNA strand breaks and cell turnover
rates may play an important role in determining the ultimate amount of DNA
damage in contaminated organisms.
SREL Reprint #1933
Sugg, D.W., R.K. Chesser, J.A. Brooks, and B.T. Grasman. 1995. The association of DNA damage to concentrations of mercury and radiocesium in largemouth bass. Environmental Toxicology and Chemistry 14:661-668.